"上海博耀生物銷售SirT1 Antibody (Mouse Specific) #2028，CST原裝品質(zhì)，價格優(yōu)惠，訂購SirT1 Antibody (Mouse Specific) #2028

"上海博耀生物銷售SirT1 Antibody (Mouse Specific) #2028，CST原裝品質(zhì)，價格優(yōu)惠，訂購SirT1 Antibody (Mouse Specific) #2028，詳情請咨詢銷售人員！
產(chǎn)品詳細(xì)參數(shù)如下>>>>

產(chǎn)品名稱：SirT1 Antibody (Mouse Specific) #2028
貨號：2028
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型： Polyclonal
規(guī)格：

No.	Size	Price
2028S	100 ul (10 western blots)	詢價

抗體應(yīng)用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IF-IC	M	Endogenous	120	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度： SirT1 Antibody (Mouse Specific) detects endogenous levels of total SirT1 protein. This antibody does not cross-react with other sirtuin proteins.
來源及純化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of mouse SirT1. Antibodies are purified by protein A and peptide affinity chromatography.
抗體背景：

The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae SIR2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging (1). SirT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53 (2,3), p300 (4), Ku70 (5), forkhead (FoxO) transcription factors (5,6), PPARγ (7), and the PPARγ coactivator-1α (PGC-1α) protein (8). Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival (2,3,5,6). Deacetylation of PPARγ and PGC-1α regulates the gluconeogenic/glycolytic pathways in the liver and fat mobilization in white adipocytes in response to fasting (7,8). SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. In addition, SirT1 activity may be regulated by phosphorylation, as it is phosphorylated at Ser27 and Ser47 in vivo; however, the function of these phosphorylation sites has not yet been determined (9).

關(guān)鍵詞：CST，抗體，一抗{byao_back}{byao_back2}

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