"上海博耀生物銷售Phospho-SHIP2 (Tyr1135) Antibody #2007，CST原裝品質，價格優(yōu)惠，訂購Phospho-SHIP2 (Tyr1135) Antibody #20

"上海博耀生物銷售Phospho-SHIP2 (Tyr1135) Antibody #2007，CST原裝品質，價格優(yōu)惠，訂購Phospho-SHIP2 (Tyr1135) Antibody #2007，詳情請咨詢銷售人員！
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產(chǎn)品名稱：Phospho-SHIP2 (Tyr1135) Antibody #2007
貨號：2007
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型： Polyclonal
規(guī)格：

No.	Size	Price
2007S	100 ul (10 western blots)	詢價

抗體應用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	160	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度： Phospho-SHIP2 (Tyr1135) Antibody detects endogenous levels of SHIP2 when phosphorylated at Tyr1135.
來源及純化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1135 of human SHIP2. Antibodies are purified by protein A and peptide affinity chromatography.
抗體背景：

SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate (1). SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus (1,2). Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif (2), followed by tyrosine phosphorylation on the NPXY motif (2). The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1 (3-5). Its effect on calcium flux, cell survival, growth, cell cycle arrest and apoptosis is mediated through the PI3K and Akt pathways (3-5). Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function (6).

關鍵詞：CST，抗體，一抗{byao_back}{byao_back2}

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