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價(jià)格:電議
所在地:上海
型號(hào):2006
更新時(shí)間:2013-07-27
瀏覽次數(shù):985
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(女士)
| No. | Size | Price |
| 2006S | 100 ul (10 western blots) | 詢價(jià) |
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
| W | H | Endogenous | 22 | Mouse IgG1 |
Bid is a pro-apoptotic “BH3 domain-only” member of the Bcl-2 family originally discovered to interact with both the anti-apoptotic family member Bcl-2 and the pro-apoptotic protein Bax (1). Bid is normally localized in the cytosolic fraction of cells as an inactive precursor and is cleaved at Asp60 by caspase-8 during Fas signaling, leading to translocation of the carboxyl terminal p15 fragment (tBid) to the mitochondrial outer membrane (2-4). Translocation of Bid is associated with release of cytochrome c from the mitochondria, leading to complex formation with Apaf-1 and caspase-9 and resulting in caspase-9 activation (5-7). Thus, Bid relays an apoptotic signal from the cell surface to the mitochondria triggering caspase activation (8,9).
關(guān)鍵詞:CST,抗體,一抗{byao_back}{byao_back2}
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